The adults-only Southernmost House is just that - the southernmost house in the U.S. Built as a judge's mansion for a quarter of a million dollars back in 1896. Five American presidents have slept there. It saw service as a Cuban nightclub called Café Cayo Hueso before its most recent reincarnation as a luxurious 18-room bed-and-breakfast with a swimming pool and tiki bar at the beach end of Duval Street.