Perched on the Embarcadero waterfront the Hotel Vitale is a world-class destination complete with spa and an award-winning Italian restaurant. The eight-story terraced building is chock-full of thoughtful details, from rooftop soaking tubs to linens laundered with hypoallergenic products. Rooms have spa-style limestone bathrooms--some with tubs for two--and 180-degree views of the city.