Book into the Axel for starters for its king-sized bed, fluffy robes and proximity to the bars, sauna and night spots of Gaixample as the Eixample District has been nicknamed.
You'll have plenty of time during the day to see the various Gaudí fantasies in the neighborhood, because night comes late in Barcelona - dinner after 8:30 pm and clubs all but comatose until at least 1 am. Lucky for you, there are plenty of bars-- LGBTQ and otherwise - that can see you through the awkward hours like the Bacon Bear Bar and La Sue.
While the sun shines, wander the shops and sights of Las Ramblas, ducking into La Boqueria, the enclosed public market, for lunch at a market restaurant or stall.
A summer option is begin your partying at the beach. Follow Las Ramblas trail to Nova Icària, the closest beach to downtown, or head to La Mar Bella, the so-called gay beach, which has a nudist section.
Line your stomach for the night ahead at one of the many excellent ethic restaurants in the neighborhood before you head out for the night.
If you're new or alone in town, you might want to book a a tour of gay bars to get your into the swing of things. After two hours, you're ready to branch out on your own until dawn. Enjoy, the Axel has a spa that will get you going again tomorrow.