This Hilton hotel caters to the business traveler with a 24-hour business center and rooms with large work desks.  It's also the largest hotel in Oregon.  You're in the middle of it all so be sure to explore your surroundings but rest assured, the two restaurants on-site provide plenty of quality options and local brews.  Note that the hotel campus is essentially split into two parts - upgrade to the Tower for fantastic downtown views if you can.