The popular, gay-owned Carpe Diem Guesthouse & Spa does brisk business with its blend of classic Cape Cod style and high-end spa amenities. Rooms are plush and cozy, with full fireplaces and nautical decor, and a full menu of massages and body treatments is available, including a Turkish steam bath, dry sauna, yoga/meditation room and Zen garden. Located in the heart of town, the Guesthouse is just a five-minute walk from Pilgrim Monument, but with a setting this pampered, you may not want to leave. Open year-round.