A sophisticated retreat tucked away in the bustling South of Market neighborhood, Hotel Palomar is popular with celebrities and jet-setters alike, offering classic comfort with an edge. Animal-print carpets and down comforters keep things luxe, and the daily free wine tasting is a relaxing touch. Be aware that their on-site cafe is far from humdrum hotel dining: it serves cutting-edge French cuisine, and has a wine list to die for.