A quirky bed and breakfast with historic flair, The Inn San Francisco has been serving guests in the Mission District since 1872. Housed in a sprawling Victorian mansion and decorated with comfortable antiques, the 21 rooms are quaint and welcoming, as is the attentive staff. Most rooms have ensuite bathrooms, and the garden cottage--which sleeps up to four adults--has a spa tub. A private garden holds a hot tub surrounded by walnut trees and rosebushes as well as a 24-hour sundeck.